Transcription factors in T-cell development. (A) Enrichment profiles of 6 selected TFs across T-cell development stages (see supplemental Figure 2 for all TFs). These TFs score above the 97.5th percentile (indicated by a horizontal dashed line) in at least one development stage and their change across the development is larger than the 85th percentile. (B) All genes scoring above the 97.5th percentile that change across development above the 85th percentile were clustered to 40 clusters using K-means. Here 3 representing clusters are shown (see supplemental Figure 3 for all clusters). (C) Transcription factor binding site analysis results for each of the 3 clusters shown in panel B. Position weight matrices are ranked by z-score and only the top 10 results in each are shown.