Figure 2
Increased frequency of induced Th17 cells in myeloma. Purified naive CD4 cells from peripheral blood mononuclear cells (PBMCs) and bone marrow mononuclear cells (BMMCs) were polarized with Th17 cocktail for 12 days. After restimulation with PMA and ionomycin, IL-17–expressing cells were measured by intracellular IL-17 staining using flow cytometry. (A) A representative dot plot analysis shows IL-17– and IFN-γ–expressing cells as percentage of CD4 cells in peripheral blood and BM samples from HD and myeloma (MM) patients. (B) Composite results presented as mean values with SEM for IL-17–expressing cells within CD4 population. *P < .05.

Increased frequency of induced Th17 cells in myeloma. Purified naive CD4 cells from peripheral blood mononuclear cells (PBMCs) and bone marrow mononuclear cells (BMMCs) were polarized with Th17 cocktail for 12 days. After restimulation with PMA and ionomycin, IL-17–expressing cells were measured by intracellular IL-17 staining using flow cytometry. (A) A representative dot plot analysis shows IL-17– and IFN-γ–expressing cells as percentage of CD4 cells in peripheral blood and BM samples from HD and myeloma (MM) patients. (B) Composite results presented as mean values with SEM for IL-17–expressing cells within CD4 population. *P < .05.

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