Rescue of inflammatory hemorrhage by minor platelet transfusion. The rpA model was studied in thrombocytopenic mice receiving transfusion of depletion-resistant platelets from IL4Rα/GPIbα-tg mice. Bars indicate the area of hemorrhage in mice at various platelet counts. Photographs (right) show representative rpA reaction spots. Bar = 5 mm. Transfusion of platelets to 5% to 8% of normal platelet count significantly prevented bleeding (P < .01). At levels of 10% to 15% circulating platelets, the hemorrhagic area was similar to nondepleted control mice (P = .15; n = 5). Error bars represent SEM.