Figure 4
Figure 4. Functional analysis of DDR1 stimulation on eosinophils from CSS patients. (A) Flow cytometry analysis of apoptotic cells by the stimulation with Fas agonistic antibody in the presence or absence of DDR1 agonistic antibody, control IgM, β1 integrin–neutralizing antibody, DDR1-blocking protein, and control protein. The x-axis indicates annexin V–positive cells, and the y-axis indicates 7AAD-positive cells. (B) Comparison of annexin V–positive cells in various conditions (*P < .01, Bonferroni-Dunn test with 1-way factorial ANOVA). (C) Comparison of GM-CSF and IL-6 production from the eosinophils of CSS patients and asthma patients in various conditions (*P < .001 as compared with no stimulation, Bonferroni-Dunn test with 1-way factorial ANOVA). Error bars indicate standard deviation.

Functional analysis of DDR1 stimulation on eosinophils from CSS patients. (A) Flow cytometry analysis of apoptotic cells by the stimulation with Fas agonistic antibody in the presence or absence of DDR1 agonistic antibody, control IgM, β1 integrin–neutralizing antibody, DDR1-blocking protein, and control protein. The x-axis indicates annexin V–positive cells, and the y-axis indicates 7AAD-positive cells. (B) Comparison of annexin V–positive cells in various conditions (*P < .01, Bonferroni-Dunn test with 1-way factorial ANOVA). (C) Comparison of GM-CSF and IL-6 production from the eosinophils of CSS patients and asthma patients in various conditions (*P < .001 as compared with no stimulation, Bonferroni-Dunn test with 1-way factorial ANOVA). Error bars indicate standard deviation.

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