Survival curves. Kaplan-Meier overall survival curves comparing CLL cases of subset no. 1, which expressed different genes of the IGHV1 or IGHV5 subgroups (IGHV1-2/IGHV1-3/IGHV1-18 or IGHV5-a), versus CLL cases expressing the aforementioned IGHV with heterogeneous HCDR3 sequences (HET HCDR3) (log-rank test = 0.0048).