Replacement mutations in IGHV and IGKV sequences of subset no. 4. (A) Shared mutations in rearranged IGHV4-34 genes expressed by subset no. 4 cases. (i) IMGT-CDR1 codon 28: Gly→Asp/Glu, 9 of 13 cases; (ii) IMGT-FR2 codon 40: Ser→Thr, 5 of 13 cases; (iii) IMGT-FR2 codon 45: Pro→Ser, 4 of 13 cases; (iv) IMGT-FR3 codon 92: Ser→Thr, 4 of 13 cases. (B). Shared mutations in rearranged IGKV2-30 genes expressed by subset no. 4 cases. (1) IMGT-CDR1 codon 31: Tyr→His, 9 of 10 cases; (2) IMGT-FR2 codon 43: Gln→His, 5 of 10 cases; (3) IMGT-FR3 codon 66: Asn→Asp, 5 of 10 cases.