T-depleted allogeneic bone marrow cells cause rejection of pre-established skin grafts. RAG-2–deficient mice were given skin grafts from C57BL/6j mice. Survival of the skin grafts was monitored over a 2- to 3-month period. Kaplan-Meier curves depict skin graft survival in mice treated with either T-depleted bone marrow (n = 6; ▪) or undepleted spleen cells (n = 7; ○). The rejection of allogeneic skin grafts after treatment with T-depleted bone marrow has been observed in 2 independent experiments.