Figure 2
![Figure 2. Concentrations of INNO-406 in the brain. (A) Concentrations of [14C]INNO-406 and [14C]imatinib mesylate in the plasma (□) and brain (▪) in SD rats were measured 2 and 4 hours after administration of 10 mg/kg of either drug (n = 3 for both). (B) Concentrations of INNO-406 in the BALB/cA Jcl-nu mice were measured 0.5, 2, 4, 6, and 8 hours after administration of 30 mg INNO-406/kg. The data shown are representative of 3 independent experiments. (C) Growth-inhibitory effects of INNO-406 (○) and imatinib mesylate (•) on Ba/F3/wt bcr-ablGFP cells. (D) Growth-inhibitory effects of INNO-406 (○) and imatinib mesylate (•) on K562GFP cells. Error bars indicate standard deviation.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/109/1/10.1182_blood-2006-03-013250/4/zh80010706040002.jpeg?Expires=1723469385&Signature=L2tpySpbTAOluxrNi~rgeGxu0FBHkcmLubnMLNFWeC~K8F3sEIpNC-dHg00OXXO0L~SBdY2fsUNUZbyEnT9SR~M~8XuB-aht6ATaivE-wVSXS606jdqy811S~fW-q6r7M0IClLFelcXI9hisF8aKBd65ESVSLCZSgGAS3ctvxwxQBRTyevWjb4FbZc4QgbTUP66ufxeQg3EdzEJxnzKyulaaTThV2CYDJegfp33NgshKXpO2WRq5GgnFyEXQFk74G8SCia5DoPiNhiBGXcvRmwvtIlLX0WwVGFL2bBx~djgygdS89O4C7sA~zQNBQuVSBjEL5Na5dHGukcFqvimDcw__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Concentrations of INNO-406 in the brain. (A) Concentrations of [14C]INNO-406 and [14C]imatinib mesylate in the plasma (□) and brain (▪) in SD rats were measured 2 and 4 hours after administration of 10 mg/kg of either drug (n = 3 for both). (B) Concentrations of INNO-406 in the BALB/cA Jcl-nu mice were measured 0.5, 2, 4, 6, and 8 hours after administration of 30 mg INNO-406/kg. The data shown are representative of 3 independent experiments. (C) Growth-inhibitory effects of INNO-406 (○) and imatinib mesylate (•) on Ba/F3/wt bcr-ablGFP cells. (D) Growth-inhibitory effects of INNO-406 (○) and imatinib mesylate (•) on K562GFP cells. Error bars indicate standard deviation.
