Schematic illustrating the tethering, association, and signaling properties of MT1-MMP on the cell surface. Following regulation by NO, MT1-MMP expression (MMP-14), localization, and activities are modulated and effect the expression levels, activities, and functions of CD44, MMP-2, MMP-9, and possibly other MMPs (MMP-7), as well as the cleavage of adhesion molecules, ECM components (blue arrows), and chemokines and cytokines (red arrows), thus affecting a wide range of epithelial, lymphocytic, and endothelial cell behaviors.