Antiapoptotic proteins, including bcl-2, bcl-XL, bcl-w, and mcl-1, prevent activation of Bax and Bak, thus inhibiting apoptosis. Pure BH3 mimetics, such as AT-101, allow activation of Bax and Bak, enhancing apoptosis. Illustration by Marie Dauenheimer.

Antiapoptotic proteins, including bcl-2, bcl-XL, bcl-w, and mcl-1, prevent activation of Bax and Bak, thus inhibiting apoptosis. Pure BH3 mimetics, such as AT-101, allow activation of Bax and Bak, enhancing apoptosis. Illustration by Marie Dauenheimer.

Close Modal
This Feature Is Available To Subscribers Only

or Create an Account

Close Modal
Close Modal