Adhesion of recombinant GpVI ectodomains (D1D2-Cam) to Toolkit-III peptides. The response is given as absorbance at 450 nm (mean ± SE). (A) Human GpVI (hD1D2) bound significantly to the following peptides: CRP (6 experiments of 6); III-16 (6/6); III-30 (6/6); III-40 (6/6); Ethicon (6/6); Horm (6/6); III-49 (6/6); III-01 (6/6); III-09 (6/6); III-04 (6/6); GPP (6/6); III-57 (6/6); III-23 (6/6); PDI (5/6); III-31 (3/6); III-10 (3/6); GFOGER (3/6); III-13 (4/6). (B) Murine GpVI (mD1D2) bound in 4 of 4 experiments to CRP but in only 3 of 4 to III-30, III-01, and III-57. Overall binding of mD1D2 was clearly lower than that of hD1D2.