LBH589 blocks cell-cycle progression of MOLT-4 and Reh cells. MOLT-4 cells (A) and Reh cells (B) were treated with indicated concentrations of LBH589 for 24 hours. Following this, cell-cycle phase distribution was determined by flow cytometry using propidium iodide staining. Results summarized in the bar graphs are representative of 3 independent experiments; the standard deviation was up to 10% (ie, 30% ± 3%).