The coupleable analogues of the BCR-ABL inhibitors retain c-ABL inhibitory potential. (A) Chemical structures of imatinib, nilotinib, dasatinib, and their coupleable analogues c-imatinib3, c-nilotinib, and c-dasatinib as well as the acetylated derivatives thereof. (B) Kinase inhibition assays for parent compounds (■/—), coupleable analogues (▴/----), and their N-acetyl derivatives (◆/…) performed on the c-ABL full-length kinase by IMAP using the AblTide substrate peptide.