Comparison of molecular and functional parameters in CLL gene profiling. (A) Supervised analysis of microarray data obtained from 20 CLL samples distinguished on the basis of molecular (ZAP-70, CD38/ZAP-70, MUT/CD38/ZAP-70) or functional (Migration) characteristics. The performance of each class separation was calculated by measuring intercluster correlation (□) and intracluster homogeneity (■). Scores range from −1 to 1, where 1 represents complete genetic overlap, 0 means lack of correlation, and −1 indicates total genetic anticorrelation. (B) Representation of the expression pattern of 24 genes differentially expressed between 6 most- and 6 least-migrating samples. Colored squares refer to intensity ratios created by dividing the gene intensities of each sample with the weighted average of the gene intensities of all other samples analyzed. Red and green colors indicate up- and down-regulation, respectively. Accession numbers are listed on the left, while gene names are on the right.