Figure 5
TSLP Tg expression leads to the accumulation of granulocytes and erythroid precursors in the spleen. Six months after reconstitution of lethally irradiated IL-7−/−, IL-7−/− K14-TSLP, or WT recipient mice with 1 × 107 BM cells from CD45.1+ mice, recipients were analyzed. All FACS profiles were gated on CD45.1+ donor cells. (A) Granulocytes (Gr-1+ CD11b+) and erythroblasts (Ter119+ CD71+) in the BM are shown. (B) Absolute number of granulocytes and erythroblasts in BM. (C) Granulocytes (Gr-1+ CD11b+) and erythroblasts (Ter119+ CD71+) in the spleen are shown. (D) Absolute number of granulocytes and erythroblasts in spleen. *P < .05; **P < .005 (Student t test). Histograms represent the mean and standard deviation from analyzing 3 animals.
