Figure 3
Figure 3. The proliferative expansion of γδ T cells induced by iDCZol+ is dependent on the mevalonate pathway. Total counts of viable γδ and αβ T cells after stimulation with iDCZol−, iDCZol+, and iDCZol+Mev+. The former only are significantly increased by iDCZol+ stimulation (see also Figure 2B). This increase is blunted by blocking the mevalonate pathway with Mev (iDCZol+ 76 000 ± 14 000; iDCZol + Mev+ 33 000 ± 18 000; P < .02). Mev treatment does not affect αβ T-cell counts. Error bars represent mean ± SEM.

The proliferative expansion of γδ T cells induced by iDCZol+ is dependent on the mevalonate pathway. Total counts of viable γδ and αβ T cells after stimulation with iDCZol−, iDCZol+, and iDCZol+Mev+. The former only are significantly increased by iDCZol+ stimulation (see also Figure 2B). This increase is blunted by blocking the mevalonate pathway with Mev (iDCZol+ 76 000 ± 14 000; iDCZol + Mev+ 33 000 ± 18 000; P < .02). Mev treatment does not affect αβ T-cell counts. Error bars represent mean ± SEM.

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