Cell-adhesion–induced p27^Kip1-associated cell-cycle arrest through down-regulating the SCF^Skp2 ubiquitin ligase pathway in primary MCL and other non-Hodgkin B-cell lymphomas. (A,B) The Cdh1, Skp2, and p27^Kip1 expressions in primary MCL (A) and DLBCL (B) cells in suspension (Sus) versus HS-5 adhesion (HS5-Ad) were analyzed by Western blot. (C) Cell-cycle distribution in DLBCL (DLBL0401) cells in suspension (Sus), or on a confluent HS-5 monolayer (HS5-Ad; 12 hours).