p80HT transgenic mice develop lymphomas. (A) Immunoblot analysis of p80HT (and p52) expression in splenic B cells (815B and 808B) and T cells (815T and 808T) from the 808 and 815 lines of transgenic mice. Levels of α-tubulin are shown as loading control. (B) Survival curve of p80HT mice and their wild-type littermates. Numbers of mice for each group are indicated. (C) Autopsy examination of a dead p80HT mouse showing markedly enlarged lymph nodes (arrows). (D) Representative examples of lymph nodes and spleens from a dead p80HT mouse and an age-matched wild-type littermate.