Abcb7 is essential for hematopoiesis. (A) Survival curve of newborn Abc7^fl animals with or without MX1-Cre induced with pI-pC. (▪) −Cre, (♦) +Cre. (B) Peripheral blood parameters of animals shown in panel A at day 11 (□) and immediately before death (▪). Values represent the mutant value expressed as a percentage of the control value. Hb indicates hemoglobin; Retic; absolute reticulocyte count; WBC, white blood cells; PLT, platelets. Femoral bone marrow in 4-week-old Abcb7^fl+/−Mx1-Cre case controlled animals induced with pI-pC. (C) −Cre, (D) +Cre. Note extreme hypocellularity in panel D.