Effects of COX-1 inhibition, TP blockade, or a combination of both on cellular composition of atherosclerotic vascular lesions in the LDLR KO mice on a high-fat diet. Percentage areas of aortic root atherosclerotic lesions occupied by collagen (A), macrophages (B), and smooth muscle cells (C). * and ** versus placebo; # versus SC-560. Results are presented as mean ± SEM.