Effects of COX-1 inhibition, TP blockade, or a combination of both on atherogenesis in LDLR KO mice. (A) Quantitation of atherosclerosis by en face method. Percentage lesion formation in mice fed for 12 weeks a high-fat diet containing SC-560 or BM-573 or a combination of both. (B) Quantitation of lesion areas of aortic cross-sections from mice fed for 12 weeks a high-fat diet containing SC-560 or BM-573 or a combination of both. *P < .01 versus placebo; **P < .01 versus SC and BM. Results are presented as mean ± SEM.