Effects of COX-1 inhibition, TP blockade, or a combination of both on serum activity levels of PON1. Compared with placebo, no significant difference was observed in LDLR KO mice fed a high-fat diet containing SC-560 or BM-573 for 12 weeks. By contrast, a statistically significant increase was found in mice receiving high-fat diet containing both drugs (*P < .01). Results are presented as mean ± SEM.