Rebound in cholesterol level correlates with response to therapy. Mean cholesterol levels ± SD, as a proportion of the day 0 level is shown for 15 newly diagnosed patients, grouped on the basis of response. Time points shown are before treatment, on day 4, after 3 days of pravastatin loading, on day 8 at the completion of the PV + Ida-HDAC therapy, and on day 14, a week after the completion of therapy. All 15 patients were measured at all 3 time points. Patients achieving CR had lower cholesterol levels at day 14 compared with those that were resistant (P = .06, 2-tailed; P = .03, 1-tailed).