Percentage of grade III/IV toxicities. Rates of grade III/IV stomatitis, infection, and other nonhematologic toxicities, within therapy courses. The left column shows the rates of these toxicities during COP, COPADM1, COPAMD2, and maintenance course that were common treatments received by all patients. The right column shows the comparative rates of these toxicities for the CYVE (standard) or mini CYVE (reduced) course received by patients with (CNS⁺) or without (CNS⁻) CNS disease at diagnosis. Reductions in stomatitis, infection, and other nonhematologic toxicities during these courses were statistically significant (P < .001, P < .01, and P < .005, respectively).