Pharmacokinetic profile of MS-275. Data were obtained from 35 patients with leukemia treated with MS-275 at dose levels ranging from 4 to 10 mg/m². (A) Concentration-time profiles of MS-275 administered orally by dose group. Data from patients treated at the same dose levels were grouped and are presented as mean values (symbol) ± SE (error bar). The legend insert shows the different symbols/lines used for each of the test dose levels. (B) Effect of drug dose on the area under the plasma concentration versus time curve of MS-275 (AUC). Each symbol represents data from an individual patient, and horizontal lines represent the median value in each dose group.