Preserved vasodilator responses to CGRP. CGRP was infused as an intravenous bolus (0.1 or 0.3 nmol/kg) to probe whether endothelium-independent vascular regulation remained normal. The responses of sickle mice and BM-S mice were no different from hemizygous controls. Pulmonary responsiveness (A) was mirrored by systemic responsiveness (B) in 5 to 6 mice per group. Numbers represent mean ± SEM.