Reversion of the phenotype of BM cells from FA-D1 mice after transplantation with genetically corrected BM cells. (A) Reversion of the MMC sensitivity of hematopoietic progenitors present in the BM of recipient mice transplanted with BRCA2-transduced FA-D1 BM cells. The figure shows the increased resistance to MMC in samples obtained 6 months after BMT, compared with samples obtained 2 months after BMT. (B) Reversion of the chromosomal instability of BM cells from mice transplanted with BRCA2-LVs. The figure represents the chromosomal instability, spontaneous and MMC-induced, in BM cells from one recipient mouse corresponding to the therapeutic and control groups (mouse 4 and mouse 9, respectively).