Correction of the in vitro proliferation defects and MMC hypersensitivity of FA-D1 BM progenitors transduced with LVs that express hBRCA2.C (A) Kinetics of ex vivo expansion of WT (○, □) and FA-D1 (, ) BM cells previously transduced with EGFP-LVs or BRCA2-LVs (circles and squares, respectively). Data from a representative experiment are shown. (B) Content in CFCs of cultures corresponding to panel A after 7 days of ex vivo expansion in the absence or presence of 10 nM MMC. Data are mean plus or minus SEM of data obtained from 5 plates per point. *Significant difference between cells transduced with EGFP and BRCA2-LVs (P < .05).