Figure 3
![Figure 3. LBW242 overcomes the protective effects of MM BM microenvironment. (A) MM.1S cells were cultured in BMSCs coated or noncoated plates for 48 hours in the presence of medium alone or with the indicated concentrations of LBW242. DNA synthesis was assessed by [3H]-thymidine uptake assay, and data represent means of triplicate cultures; bars, SD. (B) MM.1S cells were treated for 48 hours with the indicated concentrations of LBW242 or Dex, in the presence or absence of rhIL-6 or rhIGF-1, and then analyzed for viability. Shown are means ± SD of 3 independent experiments (P < .05 for all samples).](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/109/3/10.1182_blood-2006-04-015149/5/zh80030707500003.jpeg?Expires=1724192060&Signature=c7RmJkSG5h1O3iuZm9hvCb7qkzUKl2Jlxf6aEiH7ZjNMfp01wNwwkfUqzkCV0dZc9t5-B4M~kHuTfwXA1AYAGWhEszzQR75KY9OQt7GmC1qm76Bo~rpOeGvAlGm9NM9U1Kh8~-LWWMnUG5SBldI~WPsxqiKSJ0rfWqGECUAcXgntPwpgkuJDYZBCqqWk07i9iv2AGos4GHwAHDi13sK-C4vRob2C8kl~LL5l5truNMo0oK1H-IHUSQz1IN47pXjqRUk78ESN9I0IqT05urKR2JvHTr-hUsipu7cNRFxTnwxyj~ok6dUhPAPCo9QLe5ju3Y4MtY5QFDAHvl-Q-jNAew__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
LBW242 overcomes the protective effects of MM BM microenvironment. (A) MM.1S cells were cultured in BMSCs coated or noncoated plates for 48 hours in the presence of medium alone or with the indicated concentrations of LBW242. DNA synthesis was assessed by [3H]-thymidine uptake assay, and data represent means of triplicate cultures; bars, SD. (B) MM.1S cells were treated for 48 hours with the indicated concentrations of LBW242 or Dex, in the presence or absence of rhIL-6 or rhIGF-1, and then analyzed for viability. Shown are means ± SD of 3 independent experiments (P < .05 for all samples).
