Comparison of the effects of anti-CD44 mAbs IM7 and KM81 on leukocyte-endothelium interactions in the inflamed synovium of WT mice. Changes in leukocyte rolling and adhesion are shown after intravenous administration of anti-CD44 mAbs (A) IM7 and (B) KM81 (both at 200 μg) relative to changes after control rat IgG injection (200 μg). Symbols are the same as in Figure 1. The results are expressed as the ratio of changes observed after specific versus control IgG treatment at consecutive time points (n = 8 mice/group, *P < .05).