EFS for total group and subgroups of patients. (A) EFS of all 491 patients. With a median follow-up of 5.7 years, the 5-year EFS ± SE for all 491 patients treated on Protocol 95-01 was 82% ± 2%. (B) EFS for SR and HR patients. The 5-year EFS ± SE for SR patients (n = 272) was 86% ± 2% compared with 76% ± 3% for HR patients (n = 219; P = .01).