LAQ824 modulates the expression of genes involved in CD4⁺ T-cell activation in human monocyte-derived macrophages and DCs. (A) mRNA levels of genes involved in Th1/Th2 activation and migration in macrophages. (B) Protein production of IL-12p40, IP10, MIG, and MDC from macrophages and DCs after 24 hours of treatment with indicated stimuli. Representative of 4 independent experiments. (C) CD40 and CD86 surface expression (flow cytometry) in DCs after 24 of hours treatment with indicated stimuli.