Figure 4
Figure 4. Ad-siCav-1 increases paracellular permeability of BMECs. Paracellular flux of fluorescein dextran (Mwr 40 000) was performed and permeability coefficient (PC) determined for control (Ad-siLuc–treated) and Ad-siCav-1–treated cells, as described in “Materials and methods.” The change in permeability stemming from Ad-siCav-1 treatment was determined as percent change in PC compared with control (PCcontrol, 1.01 × 10−4 cm/min; PCAd-siCav-1, 1.42 × 10−4 cm/min). The data are presented as mean ± SE and represent 3 independent experiments performed in triplicate. *P < .05.

Ad-siCav-1 increases paracellular permeability of BMECs. Paracellular flux of fluorescein dextran (Mwr 40 000) was performed and permeability coefficient (PC) determined for control (Ad-siLuc–treated) and Ad-siCav-1–treated cells, as described in “Materials and methods.” The change in permeability stemming from Ad-siCav-1 treatment was determined as percent change in PC compared with control (PCcontrol, 1.01 × 10−4 cm/min; PCAd-siCav-1, 1.42 × 10−4 cm/min). The data are presented as mean ± SE and represent 3 independent experiments performed in triplicate. *P < .05.

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