Figure 2
![Figure 2. Histologic analysis of [H2-Ab1−/− → C3H] mice showed pathologic features similar to human chronic GVHD. The histologic findings of the skin (A-B), liver (C-D), and salivary glands (E-F) from [WT → C3H] mice and [H2-Ab1−/− → C3H] mice are shown. Sclerodermatous skin changes, such as epidermal atrophy, fat loss, follicular dropout, and dermal thickness (B); bile duct loss and fibrosis in the portal area and mild periportal mononuclear infiltrates in the liver (D, arrow); and lymphocyte inflammation, fibrosis, and atrophy of acinar tissue in the salivary glands (F, arrow) were observed in [H2-Ab1−/− → C3H] mice (original magnification, × 100).](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/109/4/10.1182_blood-2006-08-042853/4/zh80040708120002.jpeg?Expires=1722777691&Signature=SIMUEzl7G6bZ6l7n63vaSDSqcgA3a-eav2hCTJ0DnfOiNWh1TirhQ5s-5MUudnyptf9EJ6ZxxSLyQERUkVjmn3EpRE8jd2qa9OJ-FBXG3M7MmVIPzUYdUWJi91lwqlk81D3I8J4EswGDwZScue~UoGrQueMLAPvh9c-oa5PS7mSzZdLLoe-kiIBx0BE9u5cPqVZDk6u-8T3WTPdb0KMKj9XdpQ~84e9-9uBp8vWyqCG1b0vVmXZTkQGJkFcXyRlqzmqMgVrdxRBsddGurktBBo02b9OSbDlBwnj~c-jUwXye0RndSQbmQ2m-zITW16fRdbSC9YUsrX~4aXFL7HPNrw__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Histologic analysis of [H2-Ab1−/− → C3H] mice showed pathologic features similar to human chronic GVHD. The histologic findings of the skin (A-B), liver (C-D), and salivary glands (E-F) from [WT → C3H] mice and [H2-Ab1−/− → C3H] mice are shown. Sclerodermatous skin changes, such as epidermal atrophy, fat loss, follicular dropout, and dermal thickness (B); bile duct loss and fibrosis in the portal area and mild periportal mononuclear infiltrates in the liver (D, arrow); and lymphocyte inflammation, fibrosis, and atrophy of acinar tissue in the salivary glands (F, arrow) were observed in [H2-Ab1−/− → C3H] mice (original magnification, × 100).
