HI inhibits proliferation of BA/F3 and BA/F3p210 cells, including the mutants M351T, T315I, and E255K. Cells were exposed to the indicated concentrations of CPX (A-B) or GC7 (C-D) for 48 and 72 hours, respectively. CPX and GC7 impaired the proliferation of all tested cells independently of Bcr-Abl mutational status. CPX monotherapy rendered wt-Ba/F3 cells relatively unaffected compared with Ba/F3p210 cells at a dose range of 1 to 5 μm. Data shown are mean of 3 independent experiments. The percentage of cell growth was normalized to the growth of cells in the absence of drug treatment.