Regulation of MHC-I expression by KSHV. MHC-I transcription is activated by IFN and NF-κB signaling. In addition to posttranscriptional MHC-I regulation by the vMIRs during lytic replication, KSHV regulates MHC-I transcription. Activation of NF-κB transcription by vFLIP leads to MHC-I up-regulation, ensuring controlled viral dissemination during latency. The vFLIP activity and IFN induction of MHC-I are regulated by vIRF1, which binds CBP and inhibits MHC-I expression by blocking IRF1 and possibly NF-κB transcription.