Oncogenic Notch signaling pathways in solid tumors. Activation of Notch modulates signaling pathways that increase proliferation and inhibit apoptosis, thus contributing to neoplastic transformation. In addition, Notch activation can induce epithelial-to-mesenchymal transition (EMT) and thus promote the invasion and dissemination of cancer cells. Specific signaling pathways and abbreviations of signaling components are outlined in “The molecular and functional basis of Notch-induced oncogenesis.”