MGUS-L signature is discernible in a test cohort of patients with newly diagnosed MM enrolled in TT3. As in Figure 2, a 2-dimensional unsupervised hierarchical cluster analysis of 52 genes (rows) in CD138-enriched plasma cells from MGUS (n = 56), MM from MGUS (n = 16), and newly diagnosed MM (n = 214). Green arrows represent MGUS clusters with so-called non–MGUS-L MM.