EM011 is effective against human lymphoma tumor xenografts. Both EM011 and vinblastine reduce tumor volume in mice bearing CEM tumors (A). However, only EM011 is effective against CEM/VLB100 tumors (B). Panels C and D show that EM011 treatment is well-tolerated and mice do not suffer from body weight loss, whereas vinblastine reduces body weight significantly and causes morbidity. (E-F) Kaplan-Meier analysis reveals that EM011 confers an apparent survival advantage over vinblastine. Tumor volume is shown as mm³± SE; ^*P < .01.