Genomic copy number changes of chromosome 13 detected by array-CGH and validated by FISH in lymphoma cell lines. The heat map shows the genomic copy number changes of chromosome 13 in 5 lymphoma cell lines. Red indicates gain; green, loss; black, normal; and gray, unknown. Scale on the left shows physical distance from the telomere of the q arm. FISH analysis of metaphase chromosomes of 2 representative cell lines (Ly1 and Ly4) are shown with 2 BACs (RP11-79H7 and RP11-121J7) exhibiting gain by array-CGH, and with 2 BACs (RP-25E13 and RP11-207D10) showing gain by array-CGH in Ly1 and loss in Ly4. The average number of copies per cell, as detected by FISH analysis and the ploidy of each cell line, are tabulated.