IL-21 and IL-2 regulate expression of angiogenesis-related genes in activated ECs and tumor tissues. (A-C) Regulation of mRNA expression levels of angiogenesis factors in bFGF (10 ng/mL) stimulated SVEC4-10 after 3 days of IL-21, IL-2, or anginex treatment. Concentrations of the compounds are as indicated in previous figures: first bar represents 20 ng/mL; second bar, 200 ng/mL and anginex 25 μM. Results are relative means of at least 3 experiments (*P < .05, #P < .005, compared with bFGF). (D-F) Regulation of mRNA expression levels of angiogenesis factors in tumor tissues of EG7 tumors after PBS (n = 4), IL-21 (20 μg, n = 4), or IL-2 (IU 2000, n = 3) treatment. Results are relative means (*P < .05).