Proliferation but not migration is inhibited by IL-21 or IL-2 treatment. (A) Proliferation of angiogenically stimulated (bFGF 10 ng/mL) SVEC4-10 is inhibited by 3 days of treatment with IL-21, IL-2, or anginex. (B) Wound assay of SVEC4-10 cells. Migration of EC is not effected by treatment with IL-21 or IL-2. The angiogenesis inhibitor anginex inhibits migration of SVEC4-10 by approximately 70%. Data are relative mean values of at least 4 experiments (***P < .0005, **P < .005, *P < .05, compared with control).