Figure 3
Figure 3. β2-GPI proteolytically clipped at Lys317-Thr318 inhibits plasmin generation but not FXI activation. A schematic representation of the effect of clipped β2-GPI (cβ2-GPI) and β2-GPI on FXI activation and plasmin generation is shown. Continuous green line indicates activation; segmented green line, inhibition; \\, attenuation of inhibition; FDP, fibrin degradation products; sct-PA, single-chain tissue plasminogen activator; tct-PA, 2-chain tissue plasminogen activator; PAI-1, plasminogen activator inhibitor-1; α2-AP, α2-antiplasmin; TAFI, thrombin-activatable fibrinolysis inhibitor; TAFIa, activated TAFI. Reprinted from Shi et al59 with permission.

β2-GPI proteolytically clipped at Lys317-Thr318 inhibits plasmin generation but not FXI activation. A schematic representation of the effect of clipped β2-GPI (cβ2-GPI) and β2-GPI on FXI activation and plasmin generation is shown. Continuous green line indicates activation; segmented green line, inhibition; \\, attenuation of inhibition; FDP, fibrin degradation products; sct-PA, single-chain tissue plasminogen activator; tct-PA, 2-chain tissue plasminogen activator; PAI-1, plasminogen activator inhibitor-1; α2-AP, α2-antiplasmin; TAFI, thrombin-activatable fibrinolysis inhibitor; TAFIa, activated TAFI. Reprinted from Shi et al59  with permission.

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