Figure 2
Figure 2. Proposed mechanism of how anti–β2-GPI Abs in complex with β2-GPI may crosslink the GPIbα subunit of the GPIb-IX-V receptor on platelets to induce activation of the p38 MAPK/PLA2 and the PI3K/Akt intracellular pathways, potentially leading to thromboxane A2 production and the activation of αIIbβ3. TxA2 indicates thromboxane. Reprinted from Shi et al27 with permission.

Proposed mechanism of how anti–β2-GPI Abs in complex with β2-GPI may crosslink the GPIbα subunit of the GPIb-IX-V receptor on platelets to induce activation of the p38 MAPK/PLA2 and the PI3K/Akt intracellular pathways, potentially leading to thromboxane A2 production and the activation of αIIbβ3. TxA2 indicates thromboxane. Reprinted from Shi et al27  with permission.

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