Structure-activity relationship of solenopsin and analogs in SVR angiogenesis assay. Solenopsin and its analogs 1 to 17 were tested for their ability to inhibit the proliferation of SVR endothelial cells at 1 μg/mL, 3 μg/mL, and 6 μg/mL. Only solenopsin A exhibited dose-dependent inhibition of SVR proliferation (P < .05). Bars represent average of duplicate experiments, each performed in triplicate. Analog data not shown for brevity.