Acceleration of K-RAS–induced MPD in mice with Rce1 deficiency. Groups of Rce1^fl/flK^LSLM mice and control Rce1^fl/+K^LSLM mice were injected at weaning with pI-pC to induce MPD. (A) The concentration of white blood cells was elevated in Rce1^fl/flK^LSLM compared with Rce1^fl/+K^LSLM mice with MPD. Statistically significant changes at each time point are indicated. *P < .05; **P < .01; and ***P < .001; n = 11-27 per time point, except for the values at 42 days (n = 3 [Rce1^fl/flK^LSLM] and n = 5 (Rce1^fl/+K^LSLM). (B) Kaplan-Meier curve demonstrating reduced survival of pI-pC–injected Rce1^fl/flK^LSLM mice (median survival, 40 days; n = 12) compared with Rce1^fl/+K^LSLM mice (median survival, 54 days; n = 5).