Figure 1. Melting curves and sequences of PCR products from patients with systemic mastocytosis carrying different KIT mutations. (A) D816V KIT mutation (melting curve at 63°C) found in a patient with ISM. (B) D816Y KIT mutation (56°C) found in a patient with MCL. (C) VI815-816 insertion (56°C) found in a patient with SM-ana. (D) I817V KIT mutation (54°C) found in a patient with WDSM. Comparison with typical D816V KIT mutation and wild-type sequence (melting curve at 59°C) are shown in all panels.
Figure 1.

Melting curves and sequences of PCR products from patients with systemic mastocytosis carrying different KIT mutations. (A) D816V KIT mutation (melting curve at 63°C) found in a patient with ISM. (B) D816Y KIT mutation (56°C) found in a patient with MCL. (C) VI815-816 insertion (56°C) found in a patient with SM-ana. (D) I817V KIT mutation (54°C) found in a patient with WDSM. Comparison with typical D816V KIT mutation and wild-type sequence (melting curve at 59°C) are shown in all panels.

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