Figure 5.
Serum immunoglobulins and in vivo humoral responses. (A) IgM and subclasses of IgG immunoglobulins (Ig) were quantified in the serum collected from ADA–/– mice that received GT (–/– GT; n = 6) or BMT (–/– BMT; n = 6), 17 weeks after treatment. Serum Ig from untreated age-matched ADA+/+ mice (n = 7), 18-day-old ADA–/– mice (n = 13), or ADA+/+ mice (n = 4) are shown as controls. Each dot represents values obtained in a single mouse. Serum IgM, IgG1, and IgG3 were normal in ADA–/– GT and ADA–/– BMT mice, while IgG2a levels were not different between GT and BMT. (B) Ova-specific Ig production. ADA–/– mice treated with GT (n = 2) or BMT (n = 2) and age-matched ADA+/+ mice were challenged with Ova or adjuvant only. Ova-specific Ig belonging to different classes were measured weekly in the serum for 1 month.

Serum immunoglobulins and in vivo humoral responses. (A) IgM and subclasses of IgG immunoglobulins (Ig) were quantified in the serum collected from ADA–/– mice that received GT (–/– GT; n = 6) or BMT (–/– BMT; n = 6), 17 weeks after treatment. Serum Ig from untreated age-matched ADA+/+ mice (n = 7), 18-day-old ADA–/– mice (n = 13), or ADA+/+ mice (n = 4) are shown as controls. Each dot represents values obtained in a single mouse. Serum IgM, IgG1, and IgG3 were normal in ADA–/– GT and ADA–/– BMT mice, while IgG2a levels were not different between GT and BMT. (B) Ova-specific Ig production. ADA–/– mice treated with GT (n = 2) or BMT (n = 2) and age-matched ADA+/+ mice were challenged with Ova or adjuvant only. Ova-specific Ig belonging to different classes were measured weekly in the serum for 1 month.

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