Structure of the PLG protein and the localization of mutations reported in this study. (Reprinted from Petersen et al¹⁴  in modified form with permission of the American Society for Biochimistry and Molecular Biology and the Journal of Biological Chemistry.) Light gray circles indicate the position of mutations (missense and nonsense mutations, deletions); black triangles (insertions, splice-site mutations), PLG gene mutations; and a white circle, polymorphism 453N/D. *Mutant R134K has already been identified in a patient with ligneous conjunctivitis and vaginitis¹²  and was studied here by transient in vitro expression. **Mutant P285A has been identified recently in a patient with ligneous cervicitis¹⁵  and was studied here by transient in vitro expression.