Figure 6.
![Figure 6. Immunopathology. (A) Spleen histology day 15 after infection with LCMVcl13. Sections were fixed in formalin and then counterstained with hematoxylin and eosin. A representative white pulp region is shown for both WT and SAP– mice. Aggressive destruction of the lymphoid architecture is visible in SAP– mice, with extensive leakage of red blood cells into the white pulp. (B) Spleen cellularity was significantly reduced in SAP– mice 2 weeks after LCMVcl13 (P < .001). (Composite of 2 experiments [day 13 and 14]. WT, n = 6 [2 and 4]; SAP–, n = 5 [2 and 3].). Histologic data are representative of 3 independent experiments.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/108/9/10.1182_blood-2006-04-018929/4/zh80210602880006.jpeg?Expires=1724812296&Signature=IsQP8kfM1QxU6lPGSimkylY8K~sLmJNMt6~H50F1sxy85AZOHTx84-nISTyhm77WK~OaaEoKxX-a-W2l2682hFtLHOtsVVy~pJ347y01tNWsesvWGrYQoq8Qo-LZ~2gKLvNwRg3NjhnDa0qsrUtfy6Nuj5i4jSzFATuYxLLYrI~CsmpgPcXbxZxkDIKemcHAxKzirvAtYEHIi36SdXFigH13ASNGU-JkpAriF2qx0~5t8L80f8k1HLh6mUom4t5Zhwj8Hb0crcCHiX8ImZZFtPjhczdjILemysMGzdyFI89QicRVuob4jcNk93HIaRQMsSnoV~R9tPRVKMwZtypiVQ__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Immunopathology. (A) Spleen histology day 15 after infection with LCMVcl13. Sections were fixed in formalin and then counterstained with hematoxylin and eosin. A representative white pulp region is shown for both WT and SAP– mice. Aggressive destruction of the lymphoid architecture is visible in SAP– mice, with extensive leakage of red blood cells into the white pulp. (B) Spleen cellularity was significantly reduced in SAP– mice 2 weeks after LCMVcl13 (P < .001). (Composite of 2 experiments [day 13 and 14]. WT, n = 6 [2 and 4]; SAP–, n = 5 [2 and 3].). Histologic data are representative of 3 independent experiments.
